Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder: A Case Report.

EHegazy O, Platnick H Cureus, 2019, 11(12): e6312. DOI 10.7759/cureus.6312

Precision Newswire:
Survey Shows CBD Has Positive Impact on Migraines. Dec 16, 2020.

Cannabinoids and Migraines:
Last week, we learnt about the condition Clinical Endocannabinoid Deficiency (CECD), which is when a low functioning endocannabinoid system (ECS) manifests as disease. The three most common CECD diseases are migraine, fibromyalgia, and irritable bowel syndrome. All CECD conditions have been shown to respond positively to treatment with cannabis. This week, we’re going to look more closely at migraines.

Many people report using a variety of cannabinoids to treat headaches, including migraines. While cannabis that includes both THC and CBD is the most popular preparation, non-psychoactive products that only contain CBD may also be helpful.Although research using CBD to treat migraines is limited, a case report of a patient with neurofibromatosis found that daily use of low dose (8mg) CBD oil twice daily reduced migraine frequency from 15 to 5 episodes monthly. Another study using a very high dose (1000mg) CBD oil supplement marketed specifically for the treatment of migraines found a 23% reduction in frequency with chronic migraine sufferers experiencing a slightly greater reduction.

Fringe Commentary:
As a modulator of the ECS, there is good reason to expect that CBD could be used to treat migraines. While there isn’t much research in this area, preliminary studies have been positive. At this point, the optimal dose is unclear, but it is recommended that patients start low, track their symptoms, and increase their doses gradually if needed. Water soluble Fringe Mana or Henko CBD is likely a better choice than oil-based CBD because its absorption is much more rapid, allowing faster distribution of CBD throughout the body. More research is needed to better understand how CBD could be used both to prevent and treat migraines, but its excellent safety profile makes it an great therapeutic candidate.


Dr. Genevieve Newton, DC, PhD has spent the past 19 years as a researcher and educator in the field of nutritional sciences. A series of personal health crises led her to discover the benefits of cannabinoids, and she soon found herself engrossed in studying the endocannabinoid system and therapeutic applications of cannabis/cannabinoids in mental health, pain, sleep, and neurological disorders. She has recently taken a position as the Scientific Director at Fringe, a new medical CBD and education company.